JPET # 160465 1 Critical Cysteine Residues of Kelch - Like ECH - Associated Protein 1 in Arsenic - Sensing and Suppression of Nuclear Factor Erythroid 2 - Related Factor 2
نویسنده
چکیده
Xiaoqing He and Qiang Ma Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention (X.H., Q.M.); Department of Biochemistry, West Virginia University School of Medicine (Q.M.), Morgantown, WV JPET Fast Forward. Published on October 6, 2009 as DOI:10.1124/jpet.109.160465
منابع مشابه
Critical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2.
Arsenic activates nuclear factor erythroid 2-related factor 2 (Nrf2) to induce phase II and antioxidative genes. Here we analyzed arsenic-Kelch-like ECH-associated protein 1 (Keap1) cysteine thiol interaction in Nrf2 activation. Arsenic-based Nrf2 activators, fluorescent biarsenical labeling reagent (FlAsH) and phenylarsine oxide (PAO), were used to probe binding of arsenic to Keap1. Strong flu...
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BACKGROUND Human exposure to inorganic arsenic (iAs), a potent oxidative stressor, causes various dermal disorders, including hyperkeratosis and skin cancer. Nuclear factor-erythroid 2-related factor 1 (NRF1, also called NFE2L1) plays a critical role in regulating the expression of many antioxidant response element (ARE)-dependent genes. OBJECTIVES We investigated the role of NRF1 in arsenic-...
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